Cochrane Corner

Cochrane corner.

We will never have enough data, so we must do the best with what we acquire. Systematic reviews and meta-analyses of clinical trials represent one approach to maximizing the usefulness of clinical data. The Cochrane Collaboration thrives on the analyses of the results of tens of thousands of controlled trials in its database. The Collaboration bears the name of the British epidemiologist Archib...

Cochrane Corner Cochrane Corner: Extracts from The Cochrane Library: Intranasal Steroids for Chronic Rhinosinusitis

The Cochrane Corner is a section in the journal that highlights systematic reviews relevant to otolaryngology–head and neck surgery, with invited commentary to aid clinical decision making. This installment features a pair of related Cochrane Reviews on intranasal steroids for chronic rhinosinusitis, which identify lowto moderate-quality evidence for a beneficial effect on overall symptoms, nas...

Cochrane corner: beta-blockers for hypertension

BaCkground Beta-blockers refer to an assorted group of medications that block the action of endogenous catecholamines on beta-adrenergic receptors. The β1 and β2 receptors are the primary beta-adrenergic receptors in the human cardiovascular system. Betablockers differ in their β1/β2-receptor selectivity and vasodilatory properties. Based on this diversity, beta-blockers have been categorised i...

The Cochrane Corner in the SAMJ: Summaries of Cochrane systematic reviews for evidence-informed practice.

Cochrane corner: self-monitoring and self-management of oral anticoagulation.

BACKGROUND The introduction of point-of-care devices for the management of patients on oral anticoagulation allows self-testing by the patient at home. Patients who self-test can either adjust their medication according to a pre-determined dose-INR (international normalized ratio) schedule (self-management), or they can call a clinic to be told the appropriate dose adjustment (self-monitoring)....